Cannabidiol, better known as CBD, is one of the most exciting compounds in recent times, which can play an important role in maintaining health and treating a variety of health problems.


Cannabidiol (CBD) is one of the most researched Phytocannabinoid molecules, out of the more than 100 known molecules, produced by the cannabis plant (Cannabis Sativa L.). It is not psychoactive, it does not cause intoxication, it is not toxic even in large quantities, but it has many of the same health benefits as THC. Tetrahydrocannabinol (THC) is another active compound and is best known for its psychoactive properties.

Phytocannabinoids are formed mostly in the resin glands on the buds and flowers of the female cannabis plant, but are found in small amounts in the leaves, stems, and even in the seeds of the hemp. The seeds are used to make hemp seed oil, which is not to be confused with hemp oil (CBD oil) as a dietary supplement.

Cannabis is an extremely versatile herb with impressive therapeutic potential and a very long history. It is used in many ways in medicine, nutrition, cosmetics and other industries. More than 400 types of active compounds have been identified in terms of chemical composition. The most important of these are Phytocannabinoids such as CBD, CBDa, THC, THCa, CBDV, CBG, CBN, CBC…. but a significant role remains for the plant’s scent terpenes (Linalool, Limonene, Humulene, Beta-myrcene, Beta-Caryophyll), flavonoids, lipids and other useful ingredients.

It is important to know that Phytocannabinoid molecules are produced in an acid form in the crude plant that did not pass yet the natural drying (the combined effect of light and air) or artificial heat treatment (a process called decarboxylation). For example, CBDa (Cannabidiolic Acid) and THCA (Tetrahydrocannabinolic Acid) become active compounds upon heat exposure, thus becoming CBD and THC. Although most research is about compounds that are already active, there is a growing research about the crude intake of these acids that says it’s also very effective.

The optimal coexistence of Phytocannabinoids, terpenes and flavonoids can exert an entourage effect in the use of cannabis-derived products.

CANNABIS: Industrial hemp or marijuana?

Cannabis is a plant genus known as Cannabaceae. There are two main varieties of cannabis that are grown for human consumption, namely Cannabis indica and Cannabis sativa. Hemp is often mixed up with marijuana, although its composition and use are different. While marijuana is mainly used for recreational and medicinal purposes, hemp is found as an ingredient in dietary supplements, skin care products, clothing, building and other supplements.

Industrial hemp can be legally grown in many parts of the world because of its typical 2-4% CBD content and low THC levels (less than 0.3%), as opposed to marijuana hemp with more than 10-15% with the same or lower CBD content.

Phytocannabinoid extracted from industrial hemp collectively called hemp oil, cannabis oil, or most commonly known as CBD oil, can be used in some pharmaceuticals, medical devices, dietary supplements, cosmetics or animal products.

Folium Biosciences possesses special, protected plant genetics, so they can produce 10-20% CBD with less than 0.3% THC in organic hemp grown for organic CBD. CBD oil in USA medical products is made from a CBD-rich strain called PCR hemp. PCR stands for “phytocannabinoid-rich”, which refers to ten times the concentration of CBD. During the production and refining operations, the minimum THC content in the plant is reduced to 0.0%, so it can be safely used in accordance with legislation.

CBD oil and the Endocannabinoid system

If we look back in the past, we find out that the Endocannabinoid system was discovered by researching into the molecules of Cannabis Phytocannabinoid. That’s where the name comes from. Cannabinoid, more specifically endocannabinoid molecules (anandamide and 2-AG) are produced by the human body and vertebrate animals, which are similar in structure to the Phytocannabinoids produced by cannabis. We also have receptors (CB1 and CB2) to which the Endocannabinoid or the Phytocannabinoid molecule is directly and indirectly attached and fits like “a key in the lock”. By activating it, it initiates changes in cells that can result in a number of useful processes.

The Endocannabinoid system is a complex cellular signaling system identified by researchers in the early 1990s for the well-known cannabinoid molecule THC. Experts are still trying to understand the exact functioning of the Endocannabinoid System. But, we know that it plays a role in the regulation of many functions and processes including: sleep-wake cycle, mood, appetite and digestion, metabolism, chronic pain, inflammation and other immune reactions , learning and memory, motor control, cardiovascular function, muscle formation, bone remodeling and growth, liver function, reproductive system function, tension, skin and nerve function, social behavior.

These functions all contribute to homeostasis which refers to the stability of the internal environment. For example, when an external force, injury or pain caused by fever upsets the body’s balance, the ECR will turn on to help the body function properly. Today, experts believe that the primary role of the endocannabinoid system is to maintain homeostasis.

Research and studies are ongoing in many parts of the world and more and more people are reporting the positive effects of CBD oil. Its effect is difficult to predict before use, as it affects the consumer’s endocannabinoid system, which is very likely to be found in very different states for people of different ages and lifestyles.

Recommended uses for CBD-containing dietary supplements

It is important to note that products currently available as dietary supplements with CBD active ingredients are not considered to be medicinal products, and they cannot induce treatments under medical supervision. At the same time, there is a wealth of experience in the world that proves that when used properly, not only does it improve the condition of the patient’s body, but at times it can also eliminate the underlying causes. A lot of research is ongoing and the results are being published continuously.

In terms of bioavailability of CBD oil, there are several application methods that provide different levels of absorption to the user. The bioavailability of any active compound is the percentage of a given dose. In CBD oil, the active ingredients contain both cannabinoids and terpenes. However, for the sake of discussion, we will only talk about the bioavailability of CBD. 100% bioavailability would mean 100% CBD in the product is available to the body. The only way to achieve 100% bioavailability is by intravenous administration, that is, by direct injection into the bloodstream. Unfortunately, as a result of all other methods of consumption, a certain percentage of CBD is wasted for a variety of reasons, for example, most of it is metabolized (degraded) rapidly before it can enter the bloodstream. Let’s see the options:

Research has shown that the best bioavailability method is the inhaled application of CBD and the use of rectal suppositories. In both cases, CBD bypasses the digestive system, such as the liver, which would immediately break down valuable ingredients. Next is the absorption capacity of the active substance under the tongue, followed by the oral, ingestion and transdermal route. These possible methods are described in more detail below:

Oral administration

The easiest way to administer an active ingredient, but many factors affect its absorption. After oral administration, CBD is absorbed in the gastrointestinal tract. However, it must pass through the intestinal wall and then the liver before entering the big circulation. Being aware that the liver will chemically alter (metabolize) most components, including many medications, a decrease in the absorbed amount is to be expected.

To counteract this, 1200mg Nanoemulsion Hydro-PCR Fluid and NANOTECH CBD Capsules from USA Medical are best to use, as CBD oil is already present in a Nano emulsion formulation, resulting in up to 4 times the absorption capacity of very small CBD particles, when compared to other manufacturers’ products.


CBD oil should be ingested under the tongue. In this case, the active substance passes directly into the small blood vessels through the sublingual mucosa. This mode of administration is therefore extremely advantageous as CBD is rapidly absorbed and immediately passes into the general circulation without passing through the intestinal wall and liver.

USA Medical offers tinctures of 30 ml CBD oils with a variety of active ingredients – 500mg, 1000mg, 3000mg – so that everyone can find the most optimal product according to their needs.

Rectal application

Some agents, such as CBD, may be administered rectally, in the form of a suppository, instead of the oral route. In this case, the active ingredient is mixed with easily frozen organic shea butter or cocoa butter, which dissolves after being applied to the rectum. The inner lining of this area is lined with thin and densely veined blood vessels, so CBD is easily absorbed, and the liver is also avoided, which would immediately metabolize these particles, since the intake method allows the digestive tract to be bypassed.

USA medical CBD oil tincture products with various active ingredients are excellent to apply and are easy to make at home. All we need is a cone mold, organic shea butter or cocoa butter, a low heat cooker, and the mixing spatulas, utensils and a refrigerator for freezing.

Absorption through the skin (topical)

CBD extracts can be applied in the form of oils or creams when massaged into the skin or applied by patch applied on the skin. In such cases, we can increase the permeability of the skin – and thus enhance the CBD’s absorption capacity – by applying a warm compress to the area to be treated for a short period of time and then applying the CBD. This allows the active ingredient to pass through the skin more easily and enter the bloodstream, also bypassing the unwanted metabolic process of the liver.

USA medical CBD tinctures with different active ingredients are also a great alternative to this method of application.

Inhalation (inhalation)

CBD can be evaporated or sprayed and inhaled. The vapor is absorbed into the lungs just as oxygen is absorbed. In addition, inhalation has almost immediate effects. This is because CBD enters in the bloodstream directly through the lungs, bypassing the digestive tract.

Our 1200mg Nanoemulsion Hydro-PCR CBD product is a viable option if you have a vaporizer (not Vape / e-Cigar) above which you can inhale the CBD substance.

How long does it take for the effects of CBD oil to appear?

There are a number of important factors that play a role in determining this, with regard to the application of various methods of CBD oil. Some of these factors are related to the CBD itself – for example, when using a broad-spectrum or isolated product, inhaling it, applying it under the tongue, or possibly swallowing it orally – the other is how the human body responds to CBD. Because of unique genetics, two people will never react in the same way to CBD oil. In addition, factors such as age, health, weight, circulation and metabolism can all influence the timing of CBD oil perception. The above-mentioned aspects may affect the number of cannabinoid receptors in the body and the ability of the body to produce endocannabinoids.

As mentioned above, the effect of inhaled CBD is basically immediate. Edible products and capsules are placed in a range between 20 minutes to an hour. The tinctures effects can take 20 minutes. These figures should be considered as general guidelines as the effects of CBD can vary from person to person.